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pentobarbital will reduce the extent or effect of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Double brexpiprazole dose over 1-2 weeks if administered with a robust CYP3A4 inducer.pentobarbital will minimize the level or effect of budesonide by influencing hepatic/intestinal enzyme CYP3A4 m